Initially the relationship between breastfeeding and postpartum depression was conceptualized to be unidirectional, with postpartum depression resulting in lower rates of breastfeeding initiation and early cessation. More recently however, reports indicate that the relationship may be bidirectional in nature, suggesting that while postpartum depression may reduce rates of breastfeeding, not engaging in breastfeeding may increase the risk of postpartum depression. Additionally, there is some evidence that breastfeeding may protect against postpartum depression or assist in a swifter recovery from symptoms.

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